with phorbol esters and colony - stimulating factor 1
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چکیده
منابع مشابه
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.
متن کاملGranulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters.
Phosphatidylinositol 3-kinase (PI3-kinase) is a cytosolic enzyme that plays key roles in mediating signaling through many receptors. The heterodimeric form of PI3-kinase is made up of a regulatory subunit, p85, and a catalytic subunit, p110. Although granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to activate PI3-kinase, the mechanisms by which this activation is mediat...
متن کاملSynergistic Effect of Granulocyte - Macrophage Colony - Stimulating Factor and 1 , 25 - Dihydroxyvitamin D 3 on the Differentiation of the Human Monocytic Cell
The human monoblastlike cell line U937 can be induced to differentiate by a variety of agents including y-interferon, phorbol esters, retinoic acid, and 1 ,25-dihydroxyvitamin D3 (VD3). Incubation of U937 with 1 to 1 .000 units of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) did not induce macrophage differentiation. A synergistic effect on macrophage differentiat...
متن کاملRegulation of myelopoiesis in vitro: partial replacement of colony-stimulating factors by tumor-promoting phorbol esters.
Tumor-promoting phorbol esters such as 1 2-0-tetradecanoyl-phorbol-1 3-acetate (TPA) or phorbol-12.1 3-didecanoate (PDD) stimulate freshly isolated murine bone marrow cells in vitro to form colonies of myeloid cells in semisolid medium without added colony-stimulating factors (CSF). while phorbol and its nonpromoting derivatives do not induce marrow colony formation. TPA-stimulated colonies are...
متن کاملExpression of the macrophage-specific colony-stimulating factor in human monocytes treated with granulocyte-macrophage colony-stimulating factor.
The macrophage-specific colony-stimulating factor (CSF-1, M-CSF) regulates the survival, growth and differentiation of monocytes. We have recently demonstrated that phorbol ester induces expression of CSF-1 in human monocytes. These findings suggested that activated monocytes are capable of producing their own lineage-specific CSF. The present studies demonstrate that the granulocyte-macrophage...
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